Troy L. Ott, B.S., M.S., Ph.D.

Troy L. Ott, B.S., M.S., Ph.D.

  • Dean, College of Agricultural Sciences
201A Ag Administration Building
Shortlidge Road

University Park, PA 16802

Areas of Expertise

  • Reproductive Biology
  • Assisted Reproductive Technologies
  • Animal Science
  • Dairy production
  • Agricultural Biotechnology
  • Agricultural Sustainability
  • Graduate Training
  • Undergraduate Instruction

Publications

Effects of 3-nitrooxypropanol on rumen fermentation, lactational performance, and resumption of ovarian cyclicity in dairy cows
Journal of dairy science, Melgar, A., Harper, M. T., Oh, J., Giallongo, F., Young, M. E., Ott, T. L., Duval, S., Hristov, A. N., 2020

Mechanical shear controls bacterial penetration in mucus
Scientific reports, Figueroa-Morales, Nuris, Dominguez-Rubio, Leonardo, Ott, Troy, Aronson, Igor, 2019

Evolution of placental invasion and cancer metastasis are causally linked
Nature Ecology and Evolution, Kshitiz, , Afzal, Junaid, Maziarz, Jamie D., Hamidzadeh, Archer, Liang, Cong, Erkenbrack, Eric M., Nam, Hong, Haeger, Jan Dirk, Pfarrer, Christiane, Hoang, Thomas, Ott, Troy, Spencer, Thomas, Pavličev, Mihaela, Antczak, Douglas F., Levchenko, Andre, Wagner, Günter P., 2019

Production effects of feeding extruded soybean meal to early-lactation dairy cows
Journal of dairy science, Harper, M. T., Oh, J., Melgar, A., Nedelkov, K., Räisänen, S., Chen, X., Martins, C. M.M.R., Young, M., Ott, T. L., Kniffen, D. M., Fabin, R. A., Hristov, A. N., 2019

Symposium review
Journal of dairy science, Ott, Troy, 2019

Climate change effects on livestock in the Northeast US and strategies for adaptation
Climatic Change, Hristov, A. N., Degaetano, A. T., Rotz, C. A., Hoberg, E., Skinner, R. H., Felix, T., Li, H., Patterson, P. H., Roth, G., Hall, M., Ott, T. L., Baumgard, L. H., Staniar, W., Hulet, R. M., Dell, C. J., Brito, A. F., Hollinger, D. Y., 2018

Discrepancies and Uncertainties in Bottom-up Gridded Inventories of Livestock Methane Emissions for the Contiguous United States
Environmental Science and Technology, Hristov, Alexander Nikolov, Harper, Michael, Meinen, Robert, Day, Rick Lane, Lopes, Juliana, Ott, Troy, Venkatesh, Aranya, Randles, Cynthia A., 2017

Effects of early pregnancy on uterine lymphocytes and endometrial expression of immune-regulatory molecules in dairy heifers
Biology of reproduction, Vasudevan, Sreelakshmi, Kamat, Manasi M., Walusimbi, Sadhat S., Pate, Joy L., Ott, Troy L., 2017

Embryo mortality around the period of maintenance of the corpus luteum causes alterations to the ovarian function of lactating dairy cows1
Biology of reproduction, Wijma, Robert, Stangaferro, Matias L., Kamat, Manasi M., Vasudevan, Sreelakshmi, Ott, Troy L., Giordano, Julio O., 2016

The transcriptomic evolution of mammalian pregnancy:gene expression innovations in endometrial stromal fibroblasts
Genome biology and evolution, Kin, Koryu, Maziarz, Jamie, Chavan, Arun R., Kamat, Manasi, Vasudevan, Sreelakshmi, Birt, Alyssa, Emera, Deena, Lynch, Vincent J., Ott, Troy L., Pavlicev, Mihaela, Wagner, Günter P., 2016

Maternal immune responses to conceptus signals during early pregnancy in ruminants
Animal Reproduction, Ott, T. L., Kamat, M. M., Vasudevan, S., Townson, D. H., Pate, J. L., 2014

The Myxovirus-Resistance Protein, MX1, is a Component of Exosomes Secreted by Uterine Epithelial Cells
American Journal of Reproductive Immunology, Racicot, Karen, Schmitt, Anthony Paul, Ott, Troy, 2012

The Myxovirus Resistance Protein, MX1, Interacts with Tubulin Beta In Uterine Glandular Epithelial Cells
American Journal of Reproductive Immunology, Racicot, Karen, Ott, Troy, 2011

A path to resolution regarding the show lamb tail docking controversy
Journal of Extension, Goodwin, Jeff, Murphy, Tim, Jacobson, Ross, Jenson, Jim, Woloshuk, Jean, Peterson, Bob, Lemaster, J. Willard, Shulaw, Bill, Ott, Troy, Busboom, Jan, Newman, Jerry, Kuber, Paul, Cosner, Barney, 2007

Cellular localization and function of the antiviral protein, ovine Mx1 (oMx1)
American Journal of Reproductive Immunology, Toyokawa, Koji, Carling, Stacy J., Ott, Troy L., 2007

Regulation of interferon-stimulated genes in peripheral blood leukocytes in pregnant and bred, nonpregnant dairy cows
Journal of dairy science, Gifford, C. A., Racicot, K., Clark, D. S., Austin, K. J., Hansen, T. R., Lucy, M. C., Davies, C. J., Ott, T. L., 2007

Cellular localization and function of the antiviral protein, ovine Mx1 (oMx1)
American Journal of Reproductive Immunology, Toyokawa, Koji, Leite, Fabio, Ott, Troy L., 2007

Effect of selenium intake and fetal age on mRNA levels of two selenoproteins in porcine fetal and maternal liver
Journal of animal science, Hostetler, C. E., Michal, J., Robison, M., Ott, T. L., Kincaid, R. L., 2006

Significant association of the calpastatin gene with fertility and longevity in dairy cattle
Animal Genetics, Garcia, M. D., Michal, J. J., Gaskins, C. T., Reeves, J. J., Ott, Troy, Liu, Y., Jiang, Z., 2006

Temporal and spatial associations of oestrogen receptor alpha and progesterone receptor in the endometrium of cyclic and early pregnant mares
Reproduction, Hartt, L. S., Carling, S. J., Joyce, M. M., Johnson, G. A., Vanderwall, D. K., Ott, T. L., 2005

Bovine growth hormone treatment increased IGF-I in circulation and induced the production of a specific immune response in rainbow trout (Oncorhynchus mykiss)
Aquaculture, Biga, P. R., Peterson, B. C., Schelling, G. T., Hardy, R. W., Cain, K. D., Overturf, K., Ott, T. L., 2005

The effects of recombinant bovine somatotropin (rbST) on tissue IGF-I, IGF-I receptor, and GH mRNA levels in rainbow trout, Oncorhynchus mykiss
General and Comparative Endocrinology, Biga, Peggy R., Schelling, Gerald T., Hardy, Ronald W., Cain, Kenneth D., Overturf, Kenneth, Ott, Troy, 2004

Effects of administration of somatostatin-14 and immunoneutralization of somatostatin on endocrine and growth responses in rainbow trout
Journal of Fish Biology, Peterson, B. C., Simpson, P. R., Cain, K. D., Hardy, R. H., Schelling, G. T., Ott, Troy, 2003

Expression of the uterine Mx protein in cyclic and pregnant cows, gilts, and mares
Journal of animal science, Hicks, B. A., Etter, S. J., Carnahan, K. G., Joyce, M. M., Assiri, A. A., Carling, S. J., Kodali, K., Johnson, G. A., Hansen, T. R., Mirando, M. A., Woods, G. L., Vanderwall, D. K., Ott, T. L., 2003

The effects of chronic ethanol consumption during early pregnancy on conceptus health and uterine function in pigs
Alcoholism: Clinical and Experimental Research, Kubotsu, Stephanie L., Hu, Jianbo, Carnahan, Kevin G., DeAvila, Jeanene, Ott, Troy, Mirando, Mark A., 2003

The interferon stimulated genes (ISG) 17 and Mx have different temporal and spatial expression in the ovine uterus suggesting more complex regulation of the Mx gene
Journal of Endocrinology, Johnson, G. A., Joyce, M. M., Yankey, S. J., Hansen, T. R., Ott, T. L., 2002

Phenotypic and ultrastructural characteristics of bronchoalveolar lavage cells of lentivirus-infected lambs treated with recombinant ovine IFN-τ
Journal of Interferon and Cytokine Research, Singh, Baljit, Ott, Troy L., Bazer, Fuller W., De La Concha-Bermejillo, Andres, 2001

Expression of the antiviral protein Mx in peripheral blood mononucleár cells of pregnant and bred, non-pregnant ewes
Journal of Endocrinology, Yankey, S. J., Hicks, B. A., Carnahan, K. G., Assiri, A. M., Sinor, S. J., Kodali, K., Stellflug, J. N., Ott, T. L., 2001

Effects of recombinant ovine interferon-τ on ovine lentivirus replication and progression of disease
Journal of General Virology, Juste, Raḿon A., Ott, Troy, Kwang, Jimmy, Bazer, Fuller W., De La Concha-Bermejillo, Andrés, 2000

Ovine uterine gland knock-out model
Biology of reproduction, Gray, C. Allison, Bartol, Frank F., Taylor, Kristin M., Wiley, Anne A., Ramsey, W. Shawn, Ott, Troy L., Bazer, Fuller W., Spencer, Thomas E., 2000

Interferon tau-induced hepatocyte apoptosis in sheep
Hepatology, Kim, Hun Taek, Stoica, George, Bazer, Fuller W., Ott, Troy, 2000

Ovine osteopontin
Biology of reproduction, Johnson, Greg A., Burghardt, Robert C., Spencer, Thomas E., Newton, Gary R., Ott, Troy, Bazer, Fuller W., 1999

Differential effects of intrauterine and subcutaneous administration of recombinant ovine interferon tau on the endometrium of cyclic ewes
Biology of reproduction, Spencer, Thomas E., Stagg, Allison G., Ott, Troy, Johnson, Gregory A., Ramsey, W. Shawn, Bazer, Fuller W., 1999

Amino acid composition of the fetal pig
Journal of Nutrition, Wu, Guoyao, Ott, Troy L., Knabe, Darrell A., Bazer, Fuller W., 1999

Estradiol up-regulates estrogen receptor-α messenger ribonucleic acid in sheep endometrium by increasing its stability
Biology of reproduction, Ing, Nancy H., Ott, Troy, 1999

Intrauterine infusion of bacterial lipopolysaccharide (LPS) prior to mating has no adverse effect on fertility, fetal survival and fetal development
Journal of Reproductive Immunology, Tuo, Wenbin, Ott, Troy L., Liu, Shyh hwa, Bazer, Fuller W., 1999

Platelet-activating factor may act as an endogenous pulse generator for sheep of luteolytic PGF(2α) release
American Journal of Physiology - Endocrinology and Metabolism, Chami, O., Megevand, A., Ott, Troy, Bazer, F., O'Neill, C., 1999

Maternal dietary protein deficiency decreases nitric oxide synthase and ornithine decarboxylase activities in placenta and endometrium of pigs during early gestation
Journal of Nutrition, Wu, Guoyao, Pond, Wilson G., Flynn, Sean P., Ott, Troy, Bazer, Fuller W., 1998

Structural responses of pulmonary intravascular macrophages in lentivirus-infected and/or recombinant ovine interferon-τ-treated lambs
Anatomical Record, Singh, Baljit, Ott, Troy, Bazer, Fuller W., De La Concha-Bermejillo, Andrés, 1998

Generation of transgenic porcine chimeras using primordial germ cell- derived colonies
Biology of reproduction, Piedrahita, Jorge A., Moore, Karen, Oetama, Betty, Lee, Chang Kyu, Scales, Nannette, Ramsoondar, Jagdeece, Bazer, Fuller W., Ott, Troy, 1998

Maternal dietary protein deficiency decreases amino acid concentrations in fetal plasma and allantoic fluid of pigs
Journal of Nutrition, Wu, Guoyao, Pond, Wilson G., Ott, Troy, Bazer, Fuller W., 1998

Recombinant ovine interferon-tau (roIFN-τ) modulates lymphocyte subsets, and ovine lentivirus (OvLV)-induced lung pathology
FASEB Journal, Singh, B., Ott, Troy, Bazer, F. W., De La Concha-Bermejillo, A., 1997

Effects of exogenous recombinant ovine interferon tau on circulating concentrations of progesterone, cortisol, luteinizing hormone, and antiviral activity; interestrous interval; rectal temperature; and uterine response to oxytocin in cyclic ewes
Biology of reproduction, Ott, Troy, Fleming, J. G.W., Spencer, T. E., Joyce, M. M., Chen, P., Green, C. N.K., Zhu, D., Welsh, T. H., Harms, P. G., Bazer, F. W., 1997

Potent Anti-Feline Immunodeficiency Virus and Anti-Human Immunodeficiency Virus Effect of IFN-τ
Journal of Immunology, Pontzer, Carol H., Yamamoto, Janet K., Bazer, Fuller W., Ott, Troy L., Johnson, Howard M., 1997

Interferon tau
American Journal of Reproductive Immunology, Bazer, Fuller W., Spencer, Thomas E., Ott, Troy, 1997

Effects of recombinant interferon-τ on ovine lentivirus replication
Journal of Interferon and Cytokine Research, Juste, Ramón A., Ott, Troy, Kwang, Jimmy, Bazer, Fuller W., De La Concha-Bermejillo, Andrés, 1996

Enzyme-linked immunosorbent assay for ovine interferon-π
Journal of Interferon and Cytokine Research, Zhu, Daming, Ott, Troy L., Bazer, Fuller W., 1996

High yield expression and secretion of the ovine pregnancy recognition hormone interferon-τ by Pichia pastoris
Journal of Interferon and Cytokine Research, Van Heeke, Gino, Ott, Troy L., Strauss, Andre, Ammaturo, Domenico, Bazer, Fuller W., 1996

Placental interferons
American Journal of Reproductive Immunology, Bazer, Fuller W., Spencer, Thomas E., Ott, Troy, 1996

Effects of interferon-τ and progesterone on oestrogen-stimulated expression of receptors for oestrogen, progesterone and oxytocin in the endometrium of ovariectomized ewes
Reproduction, Fertility and Development, Spencer, Thomas E., Mirando, Mark A., Mayesc, Jary S., Watsonc, Gary H., Ott, Troy L., Bazer, F. W., 1996

Effect of Media Composition on Growth, Plasmid Stability and Ovine Interferonλ Production in Saccharomyces cerevisiae
Journal of Fermentation and Bioengineering, Chiruvolu, Vijay, Stratton, Jayne M., Ott, Troy, Bazer, Fuller W., Meagher, Michael M., 1996

Intrauterine injection of ovine interferon-τ alters oestrogen receptor and oxytocin receptor expression in the endometrium of cyclic ewes
Journal of Molecular Endocrinology, Spencer, T. E., Ing, N. H., Ott, T. L., Mayes, J. S., Becker, W. C., Watson, G. H., Mirando, M. A., Bazer, F. W., 1995

Extension of Corpus Luteum Lifespan and Reduction of Uterine Secretion of Prostaglandin F of Cows in Response to Recombinant Interferon-τ
Journal of dairy science, Meyer, M. D., Hansen, P. J., Thatcher, W. W., Drost, M., Badinga, L., Roberts, R. M., Li, J., Ott, T. L., Bazer, F. W., 1995

Structure/Function Studies with Interferon Tau
Journal of Interferon Research, Pontzer, Carol H., Ott, Troy L., Bazer, Fuller W., Johnson, Howard M., 1994

Effects of administration of human chorionic gonadotropin or progesterone before maternal recognition of pregnancy on blastocyst development and pregnancy in sheep.
Journal of Animal Science, Nephew, K. P., Cárdenas, H., McClure, K. E., Ott, Troy, Bazer, F. W., Pope, W. F., 1994

Predicted structural motif of ifnτ
Protein Engineering, Jarpe, Michael A., Johnson, Howard M., Bazer, Fuller W., Ott, Troy, Curto, Ernie V., Krishna, N. Rama, Pontzer, Carol H., 1994

Pregnancy recognition in ruminants, pigs and horses
Theriogenology, Bazer, Fuller W., Ott, Troy, Spencer, Thomas E., 1994

Retinol-binding protein gene expression in cyclic and pregnant endometrium of pigs, sheep, and cattle
Biology of Reproduction, Harney, J. P., Ott, Troy, Geisert, R. D., Bazer, F. W., 1993

Changes in progesterone and oestrogen receptor mRNA and protein during maternal recognition of pregnancy and luteolysis in ewes
Journal of Molecular Endocrinology, Ott, T. L., Zhou, Y., Mirando, M. A., Stevens, C., Harney, J. P., Ogle, T. F., Bazer, F. W., 1993

Changes in progesterone and oestrogen receptor mRNA and protein and oxytocin receptors in endometrium of ewes after intrauterine injection of ovine trophoblast interferon
Journal of Molecular Endocrinology, Miranod, M. A., Harney, J. P., Zhou, Y., Ogle, T. F., Ott, T. L., Moffatt, R. J., Bazer, F. W., 1993

Natural Killer Cell Activity of Lymphocytes Exposed to Ovine, Type I, Trophoblast Interferon
American Journal of Reproductive Immunology, TUO, WENBIN, OTT, TROY L., BAZER, FULLER W., 1993

Roles of ovine trophoblast protein-1 and oestradiol/prolactin in the establishment of pregnancy in sheep and pigs
Reproduction, Fertility and Development, Bazer, Fuller W., Mirando, Mark A., Ott, Troy L., Harney, Jacob P., Dubois, Daniel H., Schalue, Tammie K., Pontzer, Carol H., Hostetler, Chris, Johnson, Howard M., Ogle, T., 1992

Localization of an antiviral site on the pregnancy recognition hormone, ovine trophoblast protein 1
Proceedings of the National Academy of Sciences of the United States of America, Pontzer, C. H., Ott, T. L., Bazer, F. W., Johnson, H. M., 1990

Oxytocin-stimulated inositol phosphate turnover in endometrium of ewes is influenced by stage of the estrous cycle, pregnancy, and intrauterine infusion of ovine conceptus secretory proteins
Biology of reproduction, Mirando, M. A., Ott, T. L., Vallet, J. L., Davis, M., Bazer, F. W., 1990