Posted: August 20, 2020

Letter of intent due 30 days prior to application; Applications due November 4, 2020

This FOA seeks applications to experimentally correlate genomic variants with their effects on genomic function.  This will be accomplished by performing systematic perturbation; collecting data on the effects of non-coding and protein-coding genomic variation on molecular, cellular, and organismal phenotypes; generating a catalog of these variant effects; and assisting in a group predictive modeling effort using the data.  This will also be accomplished by enabling others to perform related research by sharing approaches and standards, as well as identifying methodological strengths and weaknesses.  Centers funded through this initiative will become part of the Impact of Genomic Variation on Function (IGVF) Consortium.  As members of this Consortium, functional characterization centers will be expected to work closely with one another and other Consortium components to accelerate understanding of how genomic variation impacts human health and disease through the coordination of data collection strategies and analyses. 

See full solicitation here

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