Menaquinone-7 (Vitamin K2) Production by Bacillus subtilis natto in Biofilm Reactors

Speaker: Ehsan Mahdinia, Ph.D. candidate - Agricultural and Biological Engineering, Penn State University

Date and Location

When (Date/Time)

November 17, 2017, 2:30 PM - 3:30 PM


304 Forest Resources Lab

Add to calendar


Vitamin K is an essential factor in human health. It improves heart health, may improve microstructure of bones and recently it was discovered that it has potent antitumor characteristics. Especially menaquinone-7 (MK-7), as the most potent form of vitamin K, has received significant attention, both medically and industrially in recent years. As menaquinonesare excreted by many strains of bacteria as an electron transporter, there have been numerous studies specifically concerning MK-7 production. Among these strains, Bacillus subtilis nattoseems to hold a key position. On the other hand, Bacillus subtilis, especially in static fermentations, tends to form pellicles and possibly biofilms under suitable conditions for biofilm formation, which promote MK-7 secretion but at the same time create operational and scaling up issues.